Mitochondrial DDS Opens Innovative Pharmaceutics

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

Ischemia-associated oxidative damage leading to necrosis is a major cause of catastrophic tissue loss, and elucidating its signaling mechanism is therefore of paramount importance. p53 is a central stress sensor responding to multiple insults, including oxidative stress to orchestrate apoptotic and autophagic cell death. Whether p53 can also activate oxidative stress-induced necrosis is, howeve...

[Targeting mitochondria: innovation from mitochondrial drug delivery system (DDS) to mitochondrial medicine].

Mitochondrial dysfunction has been implicated in a variety of human diseases, including cancer and neurodegenerative disorders. Effective medical therapies for such diseases will ultimately require the targeted delivery of therapeutic agents to mitochondria. This will likely be achieved through innovations in the areas of the nanotechnology of intracellular trafficking. Mitochondrial delivery s...

Modern Medicine and Pharmaceutics

Dwight Damon, DDS, MSD.

Structure that Opens the Gate and Opens the Door

Sometimes the best way to solve a problem is to look at it from a different perspective. That is certainly the case in ion channel research. Hodgkin and Huxley must have realized that 50 years ago when they looked at membrane currents with a voltage clamp, and Sakmann and Neher realized it 20 years ago when they measured Possible Symmetries of Tetrameric Channel single-channel currents with the...